Class: Biological Therapy
Generic Name: Bosutinib
Trade Name: Bosulif®
How is this drug used? Bosulif is used for the treatment ofPhiladelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in adults with resistance or intolerance to prior therapy.
What is the mechanism of action? Bosulif is a kinase inhibitor. It limits cancer growth by interfering with certain signaling pathways in cells.
How is Bosulif given (administered)? Bosulif is administered orally (by mouth) in the form of a tablet.
How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Bosulif. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
What are the most common side effects of treatment with Bosulif?
What are some of the potentially serious side effects of treatment with Bosulif?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor if you experience any side effects that bother you or don’t go away. Also tell your doctor if you experience stomach problems, signs of an infection (such as fever), signs of bleeding problems (such as such unexpected bleeding or bruising or blood in the urine or stools), signs of liver problems (such as yellowing of the skin or the whites of the eyes or dark urine), or signs of fluid retention (such as shortness of breath or cough; chest pain; swelling in the hands, ankles, feet, or entire body; or weight gain). Also tell your doctor if you notice respiratory tract infections, loss of appetite, headache, dizziness, back pain, joint pain, or itching.
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2012 CancerConnect Last updated 10/12.
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