Nearly 136,000 Americans are expected to be diagnosed with colorectal (CRC) cancer this year,1 and more than 50% will have their cancer spread to their liver.2 Many individuals with CRC involving the liver erroneously conclude that they have no treatment options other than systemic therapy. There are however several therapeutic options for the treatment of liver metastases, and others being developed in clinical trials.
The type of liver directed therapy used is determined by the size of the cancer, the number of metastases, and the location of the cancers within the liver. Patients need to understand that many advanced treatment options are only be available at cancer centers specializing in the treatment of CRC and patients should consider getting an opinion at one of these centers. For example:
SIR-Spheres® Y-90 microspheres have been added as a new treatment option in the latest National Comprehensive Cancer Network® (NCCN®) Clinical Practice Guidelines in Oncology for colon cancer and rectal cancer. SIR-Spheres Y-90 resin microspheres are a medical device used in an interventional radiology procedure known as selective internal radiation therapy (SIRT), or radioembolization, which targets high doses of radiation directly to liver tumors. The treatment consists of tens of millions of radioactive Y-90 coated resin particles, each no bigger in diameter than a human hair. SIR-Spheres Y-90 are injected into the hepatic artery, which is the main blood supply to the liver via a catheter inserted into the femoral artery through an incision in the groin. The Y-90 resin microspheres become lodged in the smaller blood vessels that surround cancer in the liver, where they deliver a high dose of radiation to the cancer, while sparing healthy liver tissue.3,4,5
Patients with CRC that has spread to the liver need to make sure they are evaluated at a cancer center that offers advanced liver directed treatment options. They should also consider the role of clinical trials.
Ongoing research is being conducted in clinical trials to find new treatments for CRC. By learning about clinical trials you can identify opportunities that advance the treatment of CRC and possibly benefit your personal prognosis.
Learn more about clinical trials: No more searching – Advanced cancer treatments can be found in clinical trials. Cure Forward can make finding them easier.
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