Class: Targeted Therapy
Generic Name: Panitumumab
Trade Name: Vectibix®
For which conditions is this drug approved? Vectibix is used for the treatment of metastatic colorectal cancer that expresses the epidermal growth factor receptor (EGFR) and that has worsened during or after fluoropyrimidine, oxaliplatin, and irinotecan chemotherapy regimens. It is not intended for the treatment of cancer that contains a KRAS gene mutation.
It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than for which it is approved may wish to discuss this issue with their physician.
What is the mechanism of action? Vectibix belongs to a class of drugs called monoclonal antibodies. Vectibix produces its anticancer effects by targeting the epidermal growth factor receptor (EGFR). EGFR is a protein found on the surface of some cells; it is important for cellular growth, replication, and spread.
How is Vectibix typically given (administered)? Vectibix is administered intravenously (into a vein). The dose depends on several factors, including the patient’s weight and ability to tolerate Vectibix. Severe infusion reactions may occur during the administration of Vectibix. Patients will be closely monitored during and after infusions.
How are patients typically monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Vectibix. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans, or other measures to assess side effects and response to therapy. In addition, patients will be monitored for the development of severe rash and allergic or severe infusion reactions (may include airway obstruction, fever, chills, or low blood pressure).
What are the most common side effects of treatment with Vectibix?
Vectibix may also cause eye or lung problems in some patients.
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Patients should inform their physician if they experience side effects that bother them or don’t go away, or if they experience:
What is a package insert? A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some of clinical trials, chemical structure, pharmacokinetics, and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2012 CancerConsultants Last updated 08/12.
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