Class: Biological Therapy
Generic Name: trametinib
Trade Name: Mekinist ®
How is this drug used? Mekinist is used for the treatment of melanoma that has metastasized or cannot surgically removed and that tests positive for certain mutations (V600E or V600K) in the BRAF gene.
What is the mechanism of action? BRAF gene mutations are common in advanced melanoma and can contribute to cancer growth. Mekinist inhibits the protein produced by the mutated gene and helps to control cancer growth.
How is Mekinist given (administered)? Mekinist is taken orally (by mouth).
How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Mekinist. Patients may have periodic blood tests, scans, and other procedures in order to assess side effects and response to therapy.
What are the most common side effects of treatment with Mekinist?
What are some of the less common but potentially serious side effects of Mekinist?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor if you experience any side effects that bother you or don’t go away. Also tell your doctor if you notice signs of heart problems (such as racing heart, shortness of breath, swelling of the feet or ankles, or lightheadedness); signs of eye problems (such as blurred vision or other vision changes); signs of lung problems (such as cough or shortness of breath); or skin changes (such as rash, redness, peeling, tenderness, or acne).
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2013 CancerConnect Last updated 07/13.
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