Class: Biological Therapy
Generic Name: Pazopanib
Trade Name: Votrient®
How is this drug used? Votrient is used for the treatment of advanced renal cell (kidney) cancer and for the treatment of advanced soft tissue sarcoma in people who have received prior chemotherapy.
What is the mechanism of action? Votrient may help slow or prevent the growth of new blood vessels, which deprives the cancer of the oxygen and nutrients it needs to grow.
How is Votrient given (administered)? Votrient is administered orally in the form of a tablet. It is taken on an empty stomach (at least one hour before or two hours after food).
How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Votrient. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
What are the most common (occur in 20% or more of patients) side effects of treatment with Votrient in people with kidney cancer?
What are the most common (occur in 20% or more of patients) side effects of treatment with Votrient in people with soft tissue sarcoma?
What are some of the less common but potentially serious side effects of Votrient?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor if you experience any side effects that bother you or don’t go away. Also immediately report symptoms of serious side effects, such as liver, heart, or bleeding problems. The package insert for this medication (described below) contains extensive lists of symptoms that may indicate a serious problem.
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2012 CancerConnect Last updated 06/12.
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